实用医学杂志2012，Vol.28Issue(22)：3692-3694,3.DOI:10.3969/j.issn.1006-5725.2012.22.006
GAL-3、CK19、HBME-1在甲状腺乳头状癌诊断中的应用价值
Diagnostic values of Gal-3、CK19、HBME-1 in papillary thyroid carcinoma
陈帅 1任建强 1潘炯1
作者信息
- 1. 200940 上海市第一人民医院宝山分院普外科
- 折叠
摘要
Abstract
Objective To investigate the applications of Gal-3 (Galectin-3)NCK19NHBME-1 in the diagnosis of papillary thyroid carcinoma by studying the different expression patterns of three molecular makers in papillary thyroid carcinoma and benign thyroid lesions. Methods Immunohistochemical staining methods (EnVision two-step Visualization Systems) were used to detect the expression of Gal-3、CK19、 HBME-1 in 80 cases of PTC and 80 cases of benign thyroid lesions. Results The expressions of Gal-3、CK19 and HBME-1 were identified in 92.5% (73/80)、97.5%(78/80) and 96.3%(77/80) of PTC cases, and in 27.5%(22/80)、 16.3%(13/80) and 13.8% (11/80) of benign thyroid lesions cases. High expressions of the three molecular makers were found in most of the PTC cases, but not found in normal thyroid specimens. The sensitivity, specificity and accuracy of the joint detection of the three molecular makers for distinguishing between PTC and benign lesions were 85.0%, 100.0% and 92.5%, respectively. Conclusions The expressions of Gal-3、CK19、HBME-1 in PTC were significantly higher than those in benign lesions, which is helpful in distinguishing between PTC and benign lesions.关键词
甲状腺乳头状癌/Galectin-3/HBME-1/CK19/免疫组化Key words
Papillary thyroid carcinoma/ Galectin-3/ HBME-1/ CK19/ Immunohistochemical引用本文复制引用
陈帅,任建强,潘炯..GAL-3、CK19、HBME-1在甲状腺乳头状癌诊断中的应用价值[J].实用医学杂志,2012,28(22):3692-3694,3.
