实用医学杂志2012，Vol.28Issue(22)：3703-3705,3.DOI:10.3969/j.issn.1006-5725.2012.22.010
辛伐他汀对兔动脉粥样硬化斑块结构及巨噬细胞移动抑制因子的影响
Study of the plaques characterization and the expression of MIF during atherosclerosis in rabbits with the intervention of simvastin
摘要
Abstract
Objective To study the effects of simvastin on atherosclerosis rabbits by analyzing the characterization of atherosclerotic plaquein and the levels of MIF (macrophage migration inhibitory factor). Methods New Zealand rabbits were randomly divided into three groups. The rabbits in control group were given basic food, and the rabbits in model group were given aortic endothelium balloon injury and high lipid diet, and simvastin were given to the treatment group. After 10 weeks, the ratio of thickness of fibrous cap and the lipid core areas were obtained by pathological observation and the levels of serum MIF were determined by ELISA. Results The rabbits in model group had the less weak thickness of fibrous cap and the greater areas of lipid core than the treatment group, and the levels of serum MIF were higher than control group and treatment group. Conclusion Simvastin can make the atherosclerotic plaques more stable by changing the characterization of plaques and the level of MIF.关键词
动脉粥样硬化/巨噬细胞移动抑制因子/易损斑块/辛伐他汀Key words
Atherosclerosis/ Macrophage migration inhibitory factor/ Vulnerable plaque/ Simvastin引用本文复制引用
周程,刘福林,李鹤飞,李亚琴,周晓东,徐占稳..辛伐他汀对兔动脉粥样硬化斑块结构及巨噬细胞移动抑制因子的影响[J].实用医学杂志,2012,28(22):3703-3705,3.基金项目
河北省2010年医学科学研究重点课题计划(编号:20100142) （编号:20100142）
