实用医学杂志2012，Vol.28Issue(23)：3888-3891,4.DOI:10.3969/j.issn.1006-5725.2012.23.013
分子标记物预测乳腺癌腋窝前哨淋巴结转移研究
Prediction of sentinel lymph node metastases in early breast cancer by primary tumor biomarkers
李学瑞 1廖宁 1张国淳 1王坤 1祖健1
作者信息
- 1. 510080,广州市,广东省人民医院肿瘤中心乳腺科
- 折叠
摘要
Abstract
Objective To decipher the interaction between the primary breast cancer biomarkers (Ki-67, PgR) and the probability of a positive sentinel lymph node (SLN) biopsy. Methods Our dataset consisted of a total number of 243 early-stage breast cancer patients with tumor size less than 5 cm between May 2005 and November 2011. All these patients underwent SLN biopsy. After surgery, factors associated with SLN metastases determined by univariate analysis were included in a multivariate model. Results There were 70 patients with positive SLN biopsy results (28.81%). By multivariate analysis, the stronger independent predictors of SLN metastases were high Ki-67 index (〉 14%) (P= 0.013) and median PgR positive (++) (P= 0.009). Conclusion Both Ki-67 and PgR could predict the SLN metastases in patients with early breast cancer. But the accuracy still required prospective validation in a larger sample.关键词
乳腺肿瘤/前哨淋巴结转移/分子标记/Ki-67/孕激素受体Key words
Breast cancer/ Sentinel lymph node metastasis/ Biomarker/ Ki-67/ Progesterone receptor引用本文复制引用
李学瑞,廖宁,张国淳,王坤,祖健..分子标记物预测乳腺癌腋窝前哨淋巴结转移研究[J].实用医学杂志,2012,28(23):3888-3891,4.
