实用医学杂志2013，Vol.29Issue(1)：56-58,3.DOI:10.3969/j.issn.1006-5725.2013.01.025
系统性红斑狼疮患者血管内皮生长因子和颈动脉内膜中层厚度的关系
Correlation between vascular endotheliat growth factor and intima-media thickness of carotid artery in patients with systemic lupus erythematosus
摘要
Abstract
Objective To investigate the serum level of vascular endothelial growth factor (VEGF) and intima-media thickness (IMT) of carotid artery in patients with systemic lupus erythematosus (SLE) and their relationship. Methods Serum levels of VEGF in 54 SLE patients (SLE group) and 28 healthy controls (control group) were detected by ELISA and IMT of carotid artery was measured by ultrasonography. Serum levels of lipids and creatinine were measured routinely. According to SLEDAI scores, SLE patients were divided into active SLE and inactive diseases. Results Levels of VEGF and value of IMT were higher in SLE group than in control group (P < 0.05). VEGF level and IMT value were higher in active SLE than in normal controls (P < 0.05 or P < 0.01). The value of IMT in active SLE was higher than that in inactive diseases (P < 0.01). VEGF level was positively correlated with IMT (r = 0.683 , P < 0.01). Conclusions VEGF may be involved in the pathogenesis of atherosclerosis in SLE patients and it can be regarded as a nontraditional risk factor for predicting atherosclerosis.关键词
红斑狼疮,系统性/血管内皮生长因子/颈动脉内膜中层厚度Key words
Lupus erythematosus, systemic/Vascular endothelial growth factor/Intima-media thickness of carotid artery引用本文复制引用
周玲,林和平,沈蕾,蔡晓峰,王林风,王鸣军..系统性红斑狼疮患者血管内皮生长因子和颈动脉内膜中层厚度的关系[J].实用医学杂志,2013,29(1):56-58,3.基金项目
2009年苏州市青年科教兴卫项目(编号:SWKQ0907) （编号:SWKQ0907）
