实用肿瘤杂志2012，Vol.27Issue(6)：593-599,7.
AIB1在乳腺良、恶性病变组织中的表达及临床意义
Expression of nuclear receptor coactivator AIB1 in breast cancer and its clinical significance
摘要
Abstract
Objective To investigate the expression of amplified in breast cancer 1 ( AIB1 ) protein in breast cancer and its clinical significance. Methods The expressions of AIB1 protein in 120 tissue specimens of breast cancer,20 specimens of normal breast tissue and 40 benign breast lesions were examined by immunohistochemistry. The associations of AIB1 expression with tumor size,histological grades,lymph nodes metastasis and genotype were analyzed. Results The expression rate of AIB1 protein in breast cancer (40.0% ) was significantly higher than those in benign lesions (15.0% ) and normal breast tissues (10.0% ) (P <0.05) . The expression of AIB1 in grade Ⅲ cancer (62. 0% ) was higher than those in grade Ⅰ (10. 5% ) and grade Ⅱ (29. 4% ) cancer (P < 0. 05). The expression rate of AIB1 protein in cases with metastatic lymph nodes (53. 8% ) was higher than that in those with no metastatic lymph nodes (14.3%) ( P < 0. 05 ) . The expression rate was higher in patients with HER2 (+) (51.5%) than that in those with HER2 ( - ) (25.0%) (P < 0. 05 ) ; however, AIB1 expression was not correlated with ER or ER/PR status ( both P > 0. 05 ) in breast cancer tissue. The over expression rate of AIB1 had correlation with sub-genotype (P <0. 05) of breast cancer. Conclusions Upregulation of AIB1 expression is involved in the carcinogenesis and development of breast cancer;it may be used as an indicator for malignant biological behavior and poor prognosis.关键词
乳腺肿瘤/病理学/基因扩增/免疫组织化学/预后/基因表达/抗药性,肿瘤/雌激素拮抗剂/治疗应用Key words
breast neoplasms/pathology/gene amplification/immunohistochemistry/prognosis/gene expression/drug resistance, neoplasm/ estrogen antagonists/therapeutic use分类
医药卫生引用本文复制引用
李庆霞,潘海燕,闫晓路,颜聪亚,苗军程,张炎,王娟,张秀智..AIB1在乳腺良、恶性病变组织中的表达及临床意义[J].实用肿瘤杂志,2012,27(6):593-599,7.基金项目
河北省科学技术厅基金(11276103D-70). （11276103D-70）
