实用肿瘤杂志2012，Vol.27Issue(6)：602-605,4.
FGFR1在乳腺癌分子亚型中的表达及意义
Expression of FGFR1 in breast cancer and its significance
摘要
Abstract
Objective To investigate the expression of FCFR1 in breast cancer and its significance. Methods The expressions of FGFR1 , ER, PR, HER2 , GST-π , TOPO Ⅱ α; in 88 specimens of invasive ductal breast carcinoma and 30 specimens of normal breast tissue were examined with immunohistochemistry S-P method. Results The positive rate of FGFR1 expression was 37. 5% in breast cancer and 10.0% in normal breast tissue. The positive rate of FGFR1 was 60. 4% in GST-π positive breast cancer and 10. 0% in GST-π negative breast cancer (P <0. 05) ;the positive rate of FGFR1 was 47. 2% in TOPO Ⅱ α positive breast cancer and 22. 9% in TOPO Ⅱ α negative breast cancer (P<0.05).The positive rates of FGFR1 in Luminal A,Luminal R,HER2 and Basal-like subtypes were 25. 0% ,35. 3% ,56. 3% ,63. 6% .respectively. The differences were statistically significant between Luminal A subtype and HER2 subtype,and between Luminal A subtype and Basal-like subtype (P <0. 05). There was no significant difference in FGFR1 expression among other subtypes(P > 0. 05). The expression of FGFR1 was not correlated with ER,PR and HER2 status,but it was positively correlated with endocrine therapy resistance ( P < 0. 05 ). Conclusion FGFR1 expression differs in various molecular subtypes of breast carcinoma, which may be used as an indicator for prognosis of breast cancer.关键词
乳腺肿瘤/病理学/癌,导管,乳腺/病理学/受体,成纤维细胞生长因子,1型/生物合成/免疫组织化学/谷胱苷肽S-转移酶pi/DNA拓扑异构酶类,Ⅱ型/受体,表皮生长因子/受体,雌激素/预后Key words
breast neoplasms/pathology/ carcinoma, ductal, breast/pathology/ receptor, fibroblast growth factor, type 1/ biosynthesis/ immunohistochemistry/ glutathione s-transferase pi/ DNA topoisomerases, type Ⅱ / receptor, epidermal growth factor/ receptors, estr分类
医药卫生引用本文复制引用
颜聪亚,张炎,李庆霞,阎晓路,苗军程,潘海燕,邢雅军..FGFR1在乳腺癌分子亚型中的表达及意义[J].实用肿瘤杂志,2012,27(6):602-605,4.基金项目
河北省科学技术厅基金(11276103D-70). （11276103D-70）
