天津中医药2013，Vol.30Issue(1)：36-39,4.DOI:10.11656/j.issn.1672-1519.2013.01.13
滋补肝肾复方对MCAO大鼠脑组织MLCP的调控作用
Regulating effect of compound prescription of nourishing liver and kidney on cerebral expression of MLCP in rats with MCAO
摘要
Abstract
[Objective] To explore the mechanism of compound prescription of nourishing liver and kidney (NLKC) promoting neural regeneration by observing the effect of neural function deficient scale, brain infarct volume, NLKC on the expression of MLCP in rats with cerebral infarction. [Methods] The 60 SD rats were randomly divided into normal control, sham operation, model and medicine groups. The rat models with middle cerebral artery occlusion were successfully established by the improved Longa EZ. The neural function deficient scale and brain infarct volume were investigated after the treatment. The treated groups were given with NLKC. Other group were given with commensurability distilled water. The expressions of MLCP in the region around the infarction were observed by immunohis-tochemical method. [Results] It was great significant to neural function and brain infarct volume between medicine group and model group(P<0.01). The difference of MLCP expression between medicine group and model group was significant(P<0.05). [Conclusion] The NLKC can promote neurogenesis by inhibiting the expression of MLCP, improve the neural function and reduce the brain infarct volume.关键词
滋补肝肾复方/脑梗死/神经再生/抑制因子/MLCPKey words
compound prescription of nourishing liver and kidney/ cerebral infarction/ neural regeneration/ inhibiting factor/ MLCP分类
医药卫生引用本文复制引用
胡怀强,周永红,王树才,曹秉振..滋补肝肾复方对MCAO大鼠脑组织MLCP的调控作用[J].天津中医药,2013,30(1):36-39,4.基金项目
国家自然科学基金资助项目(81001591) （81001591）
山东省自然科学基金项目(ZR2010HQ065). （ZR2010HQ065）
