天然产物研究与开发2012，Vol.24Issue(12)：1724-1728,5.
黄酮类化合物清除羟自由基(HO·)功能及其构效关系研究
Function-structure Association of Flavonoid Phytochemicals on Scavenging Hydroxyl Radical (HO·)
摘要
Abstract
The function-structure association of eight flavonoids including phytochemicals quercetin,isoquercitrin,rutin, hesperetin,hesperidin,naringenin,naringin and icariin on scavenging hydroxyl radical (HO · ) were systemically investigated in vitro. The results indicated that among the eight flavonoids only quercetin, rutin and isoquercitrin showed apparent scavenging HO · activity at the concentration of 260 μM with the scavenging percentages of 30. 69% ± 0. 06, 13. 70% ± 0.04 and 10.23% ± 0.03, respectively. The function-structure relationship study indicated that the C ring 3-OH group and B ring 3' -4' orthodihydroxy group of flavonoids were important for their scavenging HO o function. This study might provide certain insights for selecting effective and favorable dietary flavonoids in the prevention and treatment of related diseases.关键词
黄酮类化合物/抗自由基/结构/功能Key words
flavonoids/ antiradical/ structure/ function分类
生物科学引用本文复制引用
郭春梅,刘淑清,郭一萌,鱼红闪,孙明忠..黄酮类化合物清除羟自由基(HO·)功能及其构效关系研究[J].天然产物研究与开发,2012,24(12):1724-1728,5.基金项目
国家自然科学基金(81171957) （81171957）
辽宁省教育厅科研项目(2008S077,LS2010050) （2008S077,LS2010050）
辽宁省自然科学基金(20082158) （20082158）
