天然产物研究与开发2012，Vol.24Issue(12)：1791-1796,6.
磷脂脂质体对三种天然黄酮化合物稳定作用
The Stability Effect for Three Natural Flavonoids by Lecithin Liposomes
摘要
Abstract
The clinical usage of flavonoids is limited due to its own stability problems,and the embedding in liposomes is an important solution. In this paper,the binding properties of three natural flavonoids,quercetin,kaempferol and luteolin, with lecithin liposomes were studied, the deprotonation of phenolic hydroxyl and the capture capacity of the Al3+ of compounds in lipid environment were evaluated for the investigation of the stable mechanism of liposomes for flavonoids. The results showed that luteolin could be embedded into the lipid bilayer interior,which significantly lowered its pKa. Otherwise, quercetin and kaempferol bound only in the polar head of the lipid bilayer external,their pKa were less influenced by the liposomes. In lipid environment,the Al3+ chelation of three compounds were all significantly decreased. The reason of the chelation decrease for luteolin was deduced as that the Al3+ moved into the lipid bilayer more difficultly for the increase of membrane fluidity caused by the binding of luteolin. Therefore, liposomes could play an obvious role in the stability of luteolin, but the protection of liposomes for quercetin and kaempferol were rather weak.关键词
脂质体/黄酮化合物/结合/pKa/Al3+Key words
flavonoid/ liposomes /intaraction/pKa/Al3+分类
化学化工引用本文复制引用
龚双梅,赵良容,张荣荣,李晓波,杨昌英..磷脂脂质体对三种天然黄酮化合物稳定作用[J].天然产物研究与开发,2012,24(12):1791-1796,6.基金项目
湖北省自然科学基金项目(2010CDB10704) （2010CDB10704）
