同位素2012，Vol.25Issue(4)：234-238,242,6.
AD显像剂11C-PIB合成效率的影响因素
Optimization of the Radiosynthesis of the 2-(4-N-[11 C] methylaminophenyl)-6-hydroxybenzothiazole for AD
摘要
Abstract
11C-PIB was the standard PET radiopharmaceuticals for Alzheimer's disease(AD) imaging targeting beta-amyloid plaques. The optimization for high synthesis yield and specific activity was designed with 11CH3-Triflate as methylation agent for 11C-PIB. Synthesis for 11C-PIB were studied with home made carbon-11 synthesis module. The results showed that the amount of precursor, the temperature and pH could effect the labeling yield. The optimum reaction conditions were as fllows: with 5 g/L of precursor, pH = 7. 0, at room temperature, a yield of 65. 2% ±4. 7% (n = 8) and a specific activity of 70. 6 GBq/g (18. 0 TBq/mmol) were achieved, and radiochemical purity was over 99%. It took 30 min from 11CO2 to 11C-PIB. Single synthesis yielding was 3. 7 GBq of 11C-PIB. The quantity and quality of 11C-PIB were suitable for clinical use after optimization.关键词
阿尔茨海默病(AD)/PET/11C-PIB/合成效率Key words
Alzheimer's disease( AD)/ PET/ 11C-PIB/ synthesis yield分类
能源科技引用本文复制引用
孙慧萍,周卫华,张锦明,张晓军,陈英茂,田嘉禾..AD显像剂11C-PIB合成效率的影响因素[J].同位素,2012,25(4):234-238,242,6.基金项目
国家自然科学基金资助项目(30670586) （30670586）
