无机材料学报2013，Vol.28Issue(1)：97-102,6.DOI:10.3724/SP.J.1077.2013.12301
介孔生物玻璃/磷酸钙骨水泥多级孔复合支架的制备及其载药特性研究
Preparation of Hierarchically Porous MBG/CPC Scaffold and Its Performance on Drug Loading and Release
摘要
Abstract
Hierarchically composite scaffold (MBG/CPC) was successfully prepared by loading of mesoporous bio-active glasses (MBG) into macroporous calcium phosphate cement (CPC) with simply centrifuging method. It is revealed that MBG loading capacity on CPC and the BET surface area of MBG/CPC can reach 47.2% and 100.1 m2/g, respectively. In contrast, almost no MBG loading is detected by using traditional impregnation route. Drug loading and releasing tests show that DOX loading capacity on hierarchically composite scaffold MBG/CPC is 46 mg/g, which is 11.5 times of that on pure CPC. Importantly, a sustained drug release in vitro performance is presented on MBG/CPC.关键词
离心法/介孔/大孔/复合支架/药物装载/缓释Key words
centrifuging/ mesoporous/macroporous/ composite scaffold/ drug loading/ sustained release分类
化学化工引用本文复制引用
丁峰,李楠,李永生,施剑林..介孔生物玻璃/磷酸钙骨水泥多级孔复合支架的制备及其载药特性研究[J].无机材料学报,2013,28(1):97-102,6.基金项目
国家重大科学研究计划(2012CB933602) （2012CB933602）
