武警医学2012，Vol.23Issue(12)：1056-1059,4.
维持性血液透析患者微炎症状态与颈动脉内中膜厚度进展的相关性研究
Correlation between the micro-inflammatory state of maintenance hemodialysis patients and progression of carotid intima-media thickness
摘要
Abstract
Objective To explore the correlation between the micro - inflammatory state of patients of maintenance hemodialy-sis and progression of carotid intima - media thickness ( PROG - IMT) . Methods The high - sensitivity C - reactive protein level ( hs - CRP) of 93 standard - compliant MHD patients was measured by ELISA. According to the results, these patients were divided into normal group (30 cases, hs - CRP levels < 3 mg/L) , and micro - inflammation group (63 cases, hs - CRP levels 3-15 mg/L) , followed up from June 2008 to May 2011, Color Doppler was used to determine the patients'progression of carotid intima - media thickness ( twice before and after the experiment). PROG - IMT was observed and their serum albumin, hemoglobin, blood lipids, blood u-rea nitrogen, creatinine, calcium, phosphorus, parathyroid hormone, dialysis adequacy, blood pressure were monitored for statistical analysis. Result ( 1) In micro - inflammation group, there were 56 patients with PROG - IMT. The difference of IMT was statistically significant ( P < 0. 05 ) and positively correlated after the experiment ( P < 0. 05 ) . Five cases died of cardiovascular and cerebrovascu-lar diseases. In normal group, there were 8 patients with PROG - IMT. IMT did not change significantly after the experiment ( P > 0.05). There was one death from cardiovascular and cerebrovascular diseases. (2) PROG - IMT, hs - CRP, age, blood pressure, and low density lipoprotein were positively correlated (P <0. 05). (3) Stepwise multiple regression analysis showed that hs - CRP was a major factor affecting PROG - IMT (P <0. 05). Conclusion IMT of MHD patients with micro - inflammatory status is progressive and hs - CRP levels are the main factor that affects PROG - IMT.关键词
微炎症/颈动脉内中膜厚度/进展/血液透析/相关性Key words
micro - inflammatory/carotid intima - media thickness/ progression/ hemodialysis/ correlation分类
医药卫生引用本文复制引用
张晓东,张建荣,朱愿,宋洁,李瑛,李辉..维持性血液透析患者微炎症状态与颈动脉内中膜厚度进展的相关性研究[J].武警医学,2012,23(12):1056-1059,4.基金项目
天津市自然科学基金(09JCYBJC09900) （09JCYBJC09900）
