武警医学2012，Vol.23Issue(12)：1062-1064,3.
白藜芦醇抑制膀胱癌细胞生长增殖及影响miR-34a表达的研究
A study of resveratrol to suppress proliferation of human bladder cancer cell line T24 and to affect expression of miR-34a
摘要
Abstract
Objective To invesligale the effects of resveralrol on proliferation of human bladder cancer cell line T24,and the role of miR - 34a in its mechanism. Methods T24 cells were trealed with resveralrol in differenl concenlralions for 24 h. Cell proliferation was validated by MTT. Flow cylomelry was used Lo analyse apoptosis. The expression of miR - 34a was delet by real - lime PCR. Results Resveralrol could inhibit the proliferation of T24 in a dose dependenl manner, induce apoplosis and increase the expression of p53 significantly. Furthermore, the level of miR - 34a in T24 cells was higher in resveralrol - trealed group than that in the conlrol group. Conclusions Resveralrol can suppress the proliferation of human bladder cancer cells, which may be allribuled lo inducing apoplosis, up - regulating miR - 34a and p53.关键词
白藜芦醇/膀胱癌/细胞凋亡/miR-34a/p53Key words
resveralrol/ bladder cancer/ apoplosis/ miR-34a/ p53分类
医药卫生引用本文复制引用
王伟,李覃,李瑛,李辉..白藜芦醇抑制膀胱癌细胞生长增殖及影响miR-34a表达的研究[J].武警医学,2012,23(12):1062-1064,3.基金项目
武警后勤学院附属医院种子基金面上项目(FYM201211),武警后勤学院科研基金面上项目(WYM201016) （FYM201211）
