武警医学2013，Vol.24Issue(1)：24-26,3.
高胆红素血症患儿血清谷氨酸含量与Na+-K+-ATP酶活性的变化及临床意义
Changes and role of serum glutamate levels and Na+-K+-ATPase activities in newborns with hyperbilirubinaemia
杨辅直 1李伟生 1苏格炘 1张倩 1陈晓玲 1刘红铃1
作者信息
- 1. 510507,广州,武警广东总队医院儿科
- 折叠
摘要
Abstract
Objective To study the changes and clinical significance of serum glulamale concenlralions and Na+ - K+ - AT-Pase activities in newborns with hyperbilirubinaemia. Methods Ninety - one newborns with hyperbilirubinaemia in varying severity and 32 controls were recruited in this sludy; their serum glulamale concenlralions and Na+ - K+ - ATPase aclivilies were delecled u-sing Beckman amino acid analyzer and colorimelry. At one lime,lhey received hearing test and later interview. Results Serum glulamate concenlrations and Na+ - K+ -ATPase aclivilies were (61.34 ±11.40) μmol/L and (0.212 ±0.026) μmolPi/(mg o h) , respectively, in newborns with hyperbilirubinaemia, significaully differenl from those in conlrols (P <0. 01) , and the changes of them were closely relaled to lotal bilirubin level. The incidence of hearing disorder also increased in high bilirubin neonales. Conclusions High glulamale level and low Na+ - K+ - ATPase aclivilies in newborns wilh hyperbilirubinaemia are possibly closely relaled lo toxicily of bilirubin, the changes of them are likely lo predict early the risk of brain disease in newborns wilh hyperbilirubinaemia.关键词
高胆红素血症/谷氨酸/Na+-K+-ATP酶/新生儿Key words
hyperbilirubinaemia/ glulamate/ Na+ - K+ -ATPase/ newborns分类
医药卫生引用本文复制引用
杨辅直,李伟生,苏格炘,张倩,陈晓玲,刘红铃..高胆红素血症患儿血清谷氨酸含量与Na+-K+-ATP酶活性的变化及临床意义[J].武警医学,2013,24(1):24-26,3.
