武警医学2013，Vol.24Issue(2)：97-100,4.
肌红蛋白基因多态性与运动性肌肉损伤的相关性
Relationship between myoglobin gene polymorphism and exercise-induced muscle damage
摘要
Abstract
Objective To study the relationship between single nucleotide polymorphism (A79G) and (T109C) in the second exon of the myoglobin gene and exercise — induced muscle damage. Methods Eighty — five soldiers of CAPF performed a strenuous weight — loading exercise and the time course of serum creatine kinase ( CK) activity was measured. Myoglobin gene polymorphism was detected by polymerase chain reaction — restriction fragment length polymorphism (PCR — RFLP) method. Association between resting CK (CKpre) , maximal CK (CKpeak) , maxiaml changes in CK ( ACK) and gene polymorphism was then analysed. Results The activity of CK [ CKpre; (145 ±33) U/L] gradually increased at 24 h after strenuous exercise and reached peak value at 72 h[CKpeak: (2972±1648) U/L], which then slowly reduced, but still higher than rest level at 120 h. The genotype frequencies ( AA = 54. 1% , AG=40.0%, GG=5.9%) and allele frequencies (A = 74.1%, G=25.9%) were coincident with Hardy — Weinberg equilibrium. Compared between groups, CKpre, CKpeak and ACK in ( AG + GG) - group were all higher than those in AA genotype group ( all P <0. 01). Conclusions The single nucleotide polymorphism (A79G) in the second exon of the myoglobin gene might contribute to susceptivity of exercise — induced muscle damage. Subjects with G allele have increased risk for developing muscle damage, whereas AA genotype may have protective effects.关键词
肌红蛋白/基因多态/运动性肌肉损伤/肌酸激酶/亚临床运动性横纹肌溶解症Key words
myoglobin/ gene polymorphism/ exercise — induced muscle damage/ creatine kinase/ subclinical exertcise rhab-domyolysis分类
医药卫生引用本文复制引用
彭朋,薄海,张磊,刁秋霞,王大宁,秦永生..肌红蛋白基因多态性与运动性肌肉损伤的相关性[J].武警医学,2013,24(2):97-100,4.基金项目
武警后勤学院博士启动基金(WYB201106)和武警后勤科研项目(WJHQ2012-21) （WYB201106）
