外科理论与实践2013，Vol.18Issue(1)：46-49,4.DOI:10.3969/j.issn.1007-9610.2013.01.012
高迁移率族蛋白1在胃癌病人血清中的含量及意义
HMGB1 level in serum of patients with gastric cancer and its clinical significance
胡海青 1胡智明1
作者信息
- 1. 浙江省人民医院海宁医院外科,浙江海宁314408
- 折叠
摘要
Abstract
Objective High mobility group box-1 protein (HMGB1) is a multifunctional cytokine, which is related to cell migration and tumor invasion. We measured serum concentrations of HMGB1 in patients with gastric cancer and compared with various clinicopathological characteristics and tumor markers such as CEA and CA19-9 to evaluate its clinical significance. Methods Pre-operative serum HMGB1 levels were measured by an enzyme-linked immunosorbent assay system in 160 patients with gastric cancer and serum CEA and CA19-9 level were determined by chemiluminescence immunoassay. In 123 patients with curative resection, post-operative serum HMGB1 level was also measured. Serum HMGB1 level of 52 patients with benign gastric disease and 80 healthy controls were measured as control. Results Compared with healthy controls and the patients with benign gastric disease, serum levels of HMGB1 were significantly higher in gastric cancer patients (P<0.001). Increased serum HMGB1 level was associated with stage progression. Serum HMGB1 was significantly lower in patients with Stage I than those in stage El and IV (P<0.001). Patients with serosal invasion (P<0.001), lymph node metastasis (P<0.001) and liver metastasis (P=0.026) had significantly higher serum HMGB1 levels. Serum level of HMGB1 decreased in 123 patients with curative resection after operation, P< 0.001. Serum HMGB1 level elevated in 66.3% of the patients (106/160). The positive rate was higher than that for serum CA19-9 (14.4%, 23/160) and CEA (8.8%, 14/160), P<0.001. Conclusions Elevation of serum level of HMGB1 in gastric cancer patients and its association with tumor stage and metastasis suggested that serum HMGB1 level might be a useful marker for monitoring tumor progression in gastric cancer. 关键词
胃癌/高迁移率族蛋白1/转移Key words
Gastric cancer/ High mobility group box-1 protein/ Metastasis分类
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胡海青,胡智明..高迁移率族蛋白1在胃癌病人血清中的含量及意义[J].外科理论与实践,2013,18(1):46-49,4.
