西安交通大学学报（医学版）2013，Vol.34Issue(1)：24-28,5.
ADAM10基因对肝癌细胞HepG2生物学特性的影响
Effects of ADAM10 gene on biological characteristics of human hepatocarcinoma cell line HepG2
邵渊 1白艳霞 1刘永存 1李峰 1石磊1
作者信息
- 1. 西安交通大学医学院第一附属医院耳鼻喉科,陕西西安710061
- 折叠
摘要
Abstract
Objective To investigate the effects of ADAM10 gene on the biological characteristics including proliferation, invasion and migration of human hepatocarcinoma cell HepG2. Methods The expression of ADAM10 mRNA was suppressed by RNA interference technique in order to determine its effects on proliferation, migration and invasion of human hepatocarcinoma cell HepG2 through the cell proliferation test, cell colony stimulation test, cell invasion test and cell migration test in vitro. Results After ADAM10 gene silencing, the proliferation, invasion and migration of HepG2 cell were markedly decreased (P<0. 05). Conclusion The expression of ADAM10 gene is associated with genesis and development of hepatocarcinoma. The overexpression of ADAM10 gene could enhance the proliferation, invasion and migration of human hepatocarcinoma cell HepG2 in vitro.关键词
肝癌细胞/RNA干扰/ADAM10/增殖/侵袭/迁移Key words
hepatocarcinoma cell/ RNA interference/ ADAM10/ proliferation/ invasion/ migration分类
医药卫生引用本文复制引用
邵渊,白艳霞,刘永存,李峰,石磊..ADAM10基因对肝癌细胞HepG2生物学特性的影响[J].西安交通大学学报（医学版）,2013,34(1):24-28,5.
