西安交通大学学报（医学版）2013，Vol.34Issue(1)：34-37,4.
5-HT7受体对肠道运动的调节作用
The role of 5-HT7 receptor in modulation of intestinal motility
邹百仓 1董蕾 1李红 1王燕 1赵刚1
作者信息
- 1. 西安交通大学医学院第二附属医院消化科,陕西西安710004
- 折叠
摘要
Abstract
Objective To observe the expression of 5-hydroxytryptamine (5-HT7) receptor in the intestinal tract of rat constipation and diarrhea models so as to probe the role of 5-HT7 receptor in modulation of intestinal motility. Methods Rat model of constipation was established by gastric irrigation with cool water. Rat model of diarrhea was established by restrain stress while the contorl rats were not intervened. After gastrointestinal transiting time and feces properties were surveyed, the expression of intestinal 5-HT7 receptor was investigater by immunohis-tochemistry and realtime quantitative PCR. Results The feces properties of constipation were less and drier than those of the controls, and the gastrointestinal transiting time in constipation was longer. The number of positive cells and mRNA expression of 5-HT7 receptor in the ileum and colon of the constipation rats were higher than those of the controls (P<0.01), and higher in the colon of the constipation rats than in the diarrhea group (P<0. 01). Conclusion 5-HT7 receptor plays a role in modulating gastrointestinal tract contractility and the colonic migrating motor complex (CMMC). The gastrointestinal dyskinesis in constipation rats may be associated with a higher expression of 5-HT7 receptor in the intestines.关键词
5-HT7受体/腹泻/便秘/平滑肌收缩/结肠移行性复合运动Key words
5-hydroxytryptamine (5-HT7) receptor/ diarrhea/ constipation/ smooth muscle contractility/ colonic migrating motor complex分类
医药卫生引用本文复制引用
邹百仓,董蕾,李红,王燕,赵刚..5-HT7受体对肠道运动的调节作用[J].西安交通大学学报（医学版）,2013,34(1):34-37,4.
