西安交通大学学报（医学版）2013，Vol.34Issue(1)：106-109,4.
人参皂甙-Rd对急性缺血性脑卒中预后的影响
Effect of ginsenoside-Rd on the prognosis of acute ischemic stroke
摘要
Abstract
Objective To analyzc the effect of ginsenoside-Rd, a selective competitive Ca21 receptor antagonist, on the prognosis of acute ischemic stroke. Methods We extracted the data of ginsenoside-Rd in patients with acute ischemic stroke of randomized, double-blind, placebo-controlled, multicenter, phase Ⅱ and Ⅲ studies, with using ginsenoside-Rd or not as the prognostic variable. The clinical outcome was assessed by using the modified Rankin Scale (mRS) and categorized as good (score 0－2) or poor (score 3 － 6). Univariate and multivariate logistic regression analyses were performed to explore predictors of ischemic stroke. Results A total of 428 patients were analyzed. Of them, 341 (56.2%) had good outcome and 84(13.8%) had poor outcome. The poor outcome was associated with old age (OR-. 1.034; 95% CI: 1.003－1.066), higher NIHSS total score (OR: 1.53; 95% CI: 1.386-1.690) and the non-use of ginsenoside-Rd (OR-. 2.024; 95% CI : 1.120－3.663). Conclusion The results suggest that ginsenoside-Rd can improve the outcome of acute ischemic stroke.关键词
缺血性脑卒中/人参皂甙-Rd/预后Key words
ischemic stroke/ ginsenoside-Rd/ prognosis分类
医药卫生引用本文复制引用
刘学东,王波,李雯,白雅,侯双星,赵钢..人参皂甙-Rd对急性缺血性脑卒中预后的影响[J].西安交通大学学报（医学版）,2013,34(1):106-109,4.基金项目
国家科技重大专项(No.2008ZX09101-Z-026) （No.2008ZX09101-Z-026）
