西北国防医学杂志2013，Vol.34Issue(1)：29-32,4.
持续气道正压通气治疗代谢综合征合并阻塞性睡眠呼吸暂停综合征
Continuous positive airway pressure therapy in patients with metabolic syndrome and obstructive sleep apnea syndrome
谢学建 1殷忠 2杨晔 2李田昌2
作者信息
- 1. 解放军323医院心内科,陕西西安710054
- 2. 解放军海军总医院
- 折叠
摘要
Abstract
Objective:To investigate the clinical effect of continuous positive airway pressure therapy (CPAP) in the treatment of patients with metabolic syndrome (MetS) and obstructive sleep apnea syndrome ( OSAS). Methods: Thirty - five patients with MetS and OSAS were enrolled in this study and received CPAP therapy for 3 months. Biochemical markers were measured before and after this procedure including the plasma levels of the nitric oxide compounds ( Nox, NO2 ～ + NO3 - ) , asymmetrical dimethylarginine ( ADMA) , thiobarbituric acid reactive substance (TBARS),tumor necrosis factor - α (TNF - α) , IL - 6 and IL - 8. Results; A significant increase in plasma nitric oxide levels and a decrease in the levels of ADMA and TBARS were detected after CPAP therapy. The plasma concentrations of TNF - α, IL - 6 and IL - 8 were decreased significantly after treatment. Conclusion: Continuous positive airway pressure therapy has beneficial effects on endothelium dysfunction, inflammatory and oxidative stress in patients with MetS and OSAS.关键词
阻塞性睡眠呼吸暂停综合征/持续气道正压通气/氧化应激/炎症Key words
Obstructive sleep apnea syndrome/ Continuous positive airway pressure/ Oxidative stress/ Inflammation分类
医药卫生引用本文复制引用
谢学建,殷忠,杨晔,李田昌..持续气道正压通气治疗代谢综合征合并阻塞性睡眠呼吸暂停综合征[J].西北国防医学杂志,2013,34(1):29-32,4.
