西北国防医学杂志2013，Vol.34Issue(1)：39-41,3.
PEG-rhG-CSF预防化疗后中性粒细胞减少症的随机对照临床研究
Treatment of chemotherapy-induced neutropenia with pegylated recombinant human granulocyte colony-stimulating factor: a randomized controlled phase H clinical study
张百红 1岳红云 2王琴中 1徐佳维 1杨文元 1马澜婧1
作者信息
- 1. 兰州军区兰州总医院肿瘤科,甘肃兰州730050
- 2. 兰州军区兰州总医院眼科,甘肃兰州730050
- 折叠
摘要
Abstract
Objective: To compare the efficacy and safety of daily administration of recombinant human granulocyte colony - stimulating factor ( rhG - CSF) with single subcutaneous injection of pegylated recombinant human granulocyte colony - stimulating factor ( PEG - rhG - CSF) in patients with chemotherapy - induced neutropenia. Methods: In the randomized open - label study, 12 breast cancer patients receiving chemotherapy with TAC regimen were randomly divided into 4 groups. The patients in group A received a single subcutaneous injection of rhG - CSF from day 3 to 16. The patients in group B, C, D received subcutaneous injection of PEG - rhG - CSF (daily 60, 100 and 120(μg/kg respectively) on day 3. Results: The duration of neutropenia (absolute neutrophil count < 1. 5 ×109/L) in group A, B, C and D were 1, 2, 2 and 2. 75 days, respectively (P > 0. 05). Compared with group B, C and D, the profile of absolute neutrophil count exhibited the second peak in group A. Conclusion : A single subcutaneous injection of PEG - rhG - CSF provides neutrophil support and a safe profile comparable to regimen of daily subcutaneous injection of rhG - CSF in breast cancer patients receiving chemotherapy.关键词
乳腺肿瘤/化疗/聚乙二醇化重组人粒细胞集落刺激因子/中性粒细胞减少Key words
Breast neoplasms/ Chemotherapy/ Pegylated recombinant human granulocyte colony - stimula- ting factor/ Neutropenia分类
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张百红,岳红云,王琴中,徐佳维,杨文元,马澜婧..PEG-rhG-CSF预防化疗后中性粒细胞减少症的随机对照临床研究[J].西北国防医学杂志,2013,34(1):39-41,3.
