现代妇产科进展2013，Vol.22Issue(1)：1-5,5.
乙型肝炎疫苗和乙肝免疫球蛋白阻断乙肝病毒母婴传播的效果
Protective effect of hepatitis B vaccine and hepatitis B immunoglobulin on infants against mother-to-infant transmission of hepatitis B virus
摘要
Abstract
Objective: To investigate the protective effect of hepatitis B vaccine and hepatitis B immunoglobulin (HBIG) in routine application on infants against motlier-to-infant transmission ( MTIT) of hepatitis B virus ( HBV ) , and clarify whether HBIG in pregnancy women may reduce MTIT of HBV. Methods: Totally 250 children born to HBV-infected mothers in Zhenjiang Maternal and Child Health Hospital, during Jan. 2006 to Dec. 2010, were enrolled. Of the 250 newborn infants,69 were tested for HBV markers in peripheral blood before immunoprophylaxis. The 250 infants and their 224 mothers were followed-up and screened for HBV markers and ALT. Information including HBIG administration during pregnancy, hepatitis B vaccine and HBIG administration in each infant was collected. Results: The 250 children of HBsAg-positive mothers were 1-6 years of age (mean,3. 3±1. 6). Of the 69 children who were tested for HBV markers at birth ,4 were HBsAg-positive. During the follow-up, two children were still HBsAg-positive and also HBeAg-positive, indicating chronic HBV infection; the remaining two children became HBsAg-negative. Moreover, one HBsAg-negative infant and another one with unknown HBV serological status at birth were HBsAg-positive during follow-up. Thus, 4 (1.6%) were chronically infected with HBV; their mothers were all HBeAg-positive. Of the four infected children,two were not injected HBIG and not immunized with hepatitis B vaccine based on the standard schedule. Of the 224 mothers,215 were recorded with HBIG administration during pregnancy. The HBsAg-positive rate in 76 children of the 76 mothers who were treated with HBIG during pregnancy was 1.3% , whereas that in 142 children of the 139 women who were not treated with HBIG was 2. 1% (P>0. 05). Conclusion: The protective effect of routine immunoprophylaxis against MTIT of HBV is definite,and the failure in some children is due to the inappropriate implementation of measures. Detection of HBsAg in newborn infants is not suitable to define MTIT of HBV, which can not be reduced by HBIG administration in later pregnancy.关键词
乙型肝炎病毒/乙型肝炎免疫球蛋白/乙型肝炎疫苗/母婴传播Key words
Hepatitis B virus/Hepatitis B immunoglobulin/Hepatitis B vaccine/Mother-to-infant transmission分类
医药卫生引用本文复制引用
徐陈瑜,陈洁,温坚,陈廷美,毛旭琴,周乙华,胡娅莉..乙型肝炎疫苗和乙肝免疫球蛋白阻断乙肝病毒母婴传播的效果[J].现代妇产科进展,2013,22(1):1-5,5.基金项目
国家临床重点专科建设项目(No:2011271) （No:2011271）
江苏省医学重点专科(No:XK201102) （No:XK201102）
南京市卫生人才工程项目(No:2011024) （No:2011024）
