畜牧兽医学报2013，Vol.44Issue(1)：1-6,6.
顶复门原虫钙依赖蛋白激酶的研究进展
Research Advances in Calcium-dependent Protein Kinases of Apicomplexa
摘要
Abstract
Calcium-dependent protein kinases (CDPKs) are a large gene family, which is one kind of serine-threonine protein kinases. CDPKs have a diverse array of functions in various plants and many protozoa. With the development of bioinformatics, molecular biology and gene engineering, increasing numbers of researches about CDPKs were published recently. Increasing evidence suggests that CDPKs can regulate many crucial steps of parasite's life cycle including host cell invasion and egress, gamete formation, and gliding motility. The special structure compared with proteins in human and mammal makes CDPKs an ideal target for novel vaccine and anti-parasite therapeutic drugs. This article reviews the structures, functions and applications of Apicomplexa 's CDPKs focusing on Plasmodium, Toxoplasma gondii and Eimeria, and prospects the research and application tendency, in order to provide references for the research of the pathogene-sis and biological agents against Apicomplexan parasites.关键词
顶复门原虫/钙依赖蛋白激酶/致病抗理Key words
Apicomplexan parasites/Calcium-dependent protein kinases/pathogenesis分类
农业科技引用本文复制引用
张念章,陈佳,王萌,朱兴全,黄思扬..顶复门原虫钙依赖蛋白激酶的研究进展[J].畜牧兽医学报,2013,44(1):1-6,6.基金项目
国家自然科学基金项目(31230073 （）
31172316 （）
31101812) （）
农业部农业科研杰出人才项目 （）
中央级公益性科研院所基本科研业务费专项(2012ZL081) （2012ZL081）
中国农业科学院院长基金项目 （）
