西南国防医药2013，Vol.1Issue(1)：29-31,3.DOI:10.3969/j.issn.1004-0188.2013.01.008
HPLC法测定斑秃搽剂中米诺地尔含量
Determination of minoxidil content in liniment for alopecia areata by HPLC method
赵瑛 1谢军 1廖海燕2
作者信息
- 1. 610083,成都,成都军区总医院药剂科
- 2. 成都军区药品仪器检验所
- 折叠
摘要
Abstract
Objective To establish the method for the detection of minoxidil content in alopecia areata liniment by HPLC. Methods The content of minoxidil in three batches of alopecia areata liniment supplied by a hospital were detected by SHMADZU VP - ODS chromatographic column with the mobile phase of methanol - water( 72:28 ),the detecting wavelength of 230 nm,and the column temperature of 35 °C . Results The linear equation of minoxidil reference substance was Y = 153. 31X -42. 33l( n = 6 ),r = 0. 9999. The sample average recovery rate was 101. 94% and RSD was 0. 6% ( n = 6 ). The precision was good, and RSD was 0. 9% ( n =5 ). Conclusion The method of HPLC can accurately detect the content of minoxidil in alopecia areata liniment,which can be used as the method for the quality control of this liniment.关键词
斑秃搽剂/米诺地尔/含量/HPLCKey words
alopecia areata liniment/ minoxidilcontent/ HPLC分类
医药卫生引用本文复制引用
赵瑛,谢军,廖海燕..HPLC法测定斑秃搽剂中米诺地尔含量[J].西南国防医药,2013,1(1):29-31,3.
