新医学2012，Vol.43Issue(11)：783-787,5.DOI:10.3969/g.issn.0253-9802.2012.11.009
早期营养干预对小于胎龄儿大鼠胰岛β细胞功能和形态的影响
The long-term functional and morphological effects of early nutrition interference on pancreatic β cells in the SGA rats
摘要
Abstract
Objective: To investigate the functional and morphological effect of early nutrition interference on pancreatic cells in SGA rats at 4 weeks old (in the infancy) and 12 weeks old (in the adulthood). Methods: Calorie diets were given neonatal SCA rats for four weeks. Longitudinal observation was carried out on the physical development, fasting blood glucose, insulin and insulin resistance index (HOMA-IR), β cell insulin secretion index ( HBCI) and morphological changes of the pancreatic β cells when the rats were 4 and 12 weeks old. Results: The weight and height of the SGA rats in the early protein interference group (Group A) developed in reasonable way, no overweight appeared; while insulin resistance was observed in the SGA rats in the control group ( Group B) without early nutrition interference, in which serum insulin level (9. 31 ±0. 72) and HOMA-IR (2. 34 ±0.46) were significantly higher than those in Group C (7. 30 ±0.58 and 1.77 ±0. 36, respectively, P <0.01). There was no significant difference revealed islet size, pancreatic β cell proportion, fasting blood glucose, insulin, HOMA-IR or HBCI between Group A and Group C (P >0. 05). Conclusion; Provision of calorie diets like high protein as nutrition interference in the early period (the window period) and basic diets during non-development period not only meets the need of growing but also promote the recovery of the fetal impaired pancreatic β cells, avoiding or delaying the IR in the adulthood.关键词
营养干预/小于胎龄儿/胰岛β细胞/功能/形态Key words
Nutrition interference/ Small for gestaional age/ Pancreatic β cells/ Function/引用本文复制引用
莫清萍,丘小汕,余慕雪,刘艳薇,谭惠珍,董淑红..早期营养干预对小于胎龄儿大鼠胰岛β细胞功能和形态的影响[J].新医学,2012,43(11):783-787,5.基金项目
广东省科技计划项目(2008B060600062) （2008B060600062）
