疑难病杂志2013，Vol.12Issue(2)：117-119,3.DOI:10.3969/j.issn.1671-6450.2013.02.014
FOLFOX方案肝动脉化疗栓塞并留管灌注联合替吉奥治疗胃癌术后肝转移的临床疗效评价
Clinical evaluation of TACE and arterial infusion chemotherapy with FOLFOX regimen through indwelling catheter combined with S1 in the treatment of hepatic metastasis after gastric resection
郑琳 1黎海亮 1郭晨阳 1肖金成 1程洪涛 1胡鸿涛 1宗登伟 1余朴1
作者信息
- 1. 450008,郑州,河南省肿瘤医院放射介入科
- 折叠
摘要
Abstract
Objective To assess the therapeutic effect of TACE and arterial infusion chemotherapy with FOLFOX regimen through indwelling catheter combined with Sl in the treatment of hepatic metastasis after gastric resection. Methods Sixty cases with hepatic metastasis after gastric resection were retrospectively analyzed. In group A ( TACE and arterial infusion chemotherapy with FOLFOX regimen through indwelling catheter combined with Sl group, n = 32 ), the catheter was inserted into tumor feeding artery using Seldinger technique, oxaliplatin 50 mg and lipiodol were used for chemo-embolization treatment. Subsequently the catheter tip was indwelled in the common hepatic artery. Patients received continuous hepatic arterial infusion of oxaliplatin 100 mg 2 hours and floxuridine 3. 0 g 44 hours. Calcium folinate 300 mg was given by intravenous drip before infusing floxuridine. One week later, Sl was taken orally 40 mg twice daily for 2 weeks, then stop one week are the one cycle. In group B ( TACE and arterial infusion chemotherapy group, n = 28 ), the same chemotherapy drugs were used for chemo-embolization. Patients received common hepatic arterial infusion of oxaliplatin 100 mg and floxuridine 1.0 g. Every four weeks treatment was repeated once as a cycle. All patients received four course of treatment. After treatment, efficiency was evaluated with images according to mRECIST standard. The patients were followed up for 14 months. Short term effect, one year survival rate, time to progression ( TTP ) were compared between two groups. Results The effective rate of group A and group B was 81. 25% and 57. 14% respectively ( P <0. 05 ). The survival rate for one year in group A was 96. 88% , but in group B was 75.00% ( P <0.05 ). The TTP in group A was ( 11.51 0.48 ) months, but in group B was ( 7. 87 0. 58 ) months ( P <0. 05 ). There were no significant difference in adverse events between two groups ( P >0. 05 ). Conclusion The treatment effects of hepatic metastasis after gastric resection by TACE and arterial infusion chemotherapy with FOLFOX regimen through indwelling catheter combined with Sl was better than by TACE and arterial infusion chemotherapy. This treatment method was valuable for further research and application.关键词
胃癌术后/肝转移癌/FOLFOX方案/肝动脉化疗栓塞/留管灌注/替吉奥Key words
Postoperative gastric carcinoma/ Hepatic metastases/ FOLFOX regimen/ TACE/ Indwelling catheter/ Sl引用本文复制引用
郑琳,黎海亮,郭晨阳,肖金成,程洪涛,胡鸿涛,宗登伟,余朴..FOLFOX方案肝动脉化疗栓塞并留管灌注联合替吉奥治疗胃癌术后肝转移的临床疗效评价[J].疑难病杂志,2013,12(2):117-119,3.
