疑难病杂志2013，Vol.12Issue(3)：172-174,3.DOI:10.3969/j.issn.1671-6450.2013.03.002
冠心病心绞痛患者血浆白细胞介素-6和单核细胞趋化因子-1变化及其临床意义
The expression and significance of plasma interleukin-6 and monocyte chemotactic factor-1 in patients with coronary heart disease
摘要
Abstract
Objective To explore the role of interleukin-6 ( IL-6 ) and monocyte chemotactic factor-1 ( MCP-1 ) in the mechanism of patients with coronary heart disease ( CHD ). Methods 70 patients who diagnosed as angina pectoris by coronary angiography were selected, among them, there were 36 cases with stable angina pectoris( SAP group ), 34 cases with unstable angina pectoris ( UAP group ). At the same time, 30 cases with normal coronary angiography were selected as control group. The level of IL-6 and MCP-1 were measured by enzyme linked immunosorbant assay ( ELISA ), respectively. Results The mean plasma levels of IL-6 and MCP-1[ ( 18. 12 2. 62 ) pg/L, ( 25. 63 4. 76 ) pg/L ] in UAP group were significantly higherthan those [( 14.98 2.54) pg/L, (21.78 4. 53 ) pg/L ] of SAP group ( P <0.0l), and both were higher than those of control group[ ( 11. 68 2. 51 ) pg/L, ( 15. 71 4. 34 ) pg/L, P < 0. 01 ]. Conclusion Inflammatory mediators might play an important role in the pathogenesis of CHD, IL-6 and MCP-1 were more significant to reflect the stability of atherosclerotic plaque and the severity of coronary artery disease.关键词
冠心病/心绞痛/白细胞介素-6/单核细胞趋化因子-1Key words
Coronary heart disease/ Angina pectoris/ Interleukin-6/ Monocyte chemotactic factor-1引用本文复制引用
刘丽军,裴利敏,信栓力,常超,王桂东,朱洁莹,李敏,李琴,王晓丽,张兰华..冠心病心绞痛患者血浆白细胞介素-6和单核细胞趋化因子-1变化及其临床意义[J].疑难病杂志,2013,12(3):172-174,3.基金项目
河北省医学科学研究重点课题计划(No.07150) （No.07150）
