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Quantitation of bivalirudin, a novel anticoagulant peptide,in human plasma by LC-MS/MS: Method development,validation and application to pharmacokinetics

Xiao-Jiao Li Yan-Tong Sun Lei Yin Xue-Ju Zhang Yan Yang J.Paul Fawcett Yi-Min Cui Jing-Kai Gu

药物分析学报(英文)2013,Vol.3Issue(1):1-8,8.
药物分析学报(英文)2013,Vol.3Issue(1):1-8,8.

Quantitation of bivalirudin, a novel anticoagulant peptide,in human plasma by LC-MS/MS: Method development,validation and application to pharmacokinetics

Quantitation of bivalirudin, a novel anticoagulant peptide,in human plasma by LC-MS/MS: Method development,validation and application to pharmacokinetics

Xiao-Jiao Li 1Yan-Tong Sun 2Lei Yin 1Xue-Ju Zhang 2Yan Yang 3J.Paul Fawcett 2Yi-Min Cui 1Jing-Kai Gu2

作者信息

  • 1. Clinical Pharmacology Center, Research Institute of Translational Medicine, The First Bethune Hospital of Jilin University,Changchun 130061, PR China
  • 2. Research Center for Drug Metabolism, College of Life Science, Jilin University, Changchun 130012, PR China
  • 3. Clinical Pharmacology Center, Research Institute of Translational Medicine, The First Bethune Hospital of Jilin University,Changchun 130061, PR China
  • 折叠

摘要

关键词

Bivalirudin/LC-MS/MS/Pharmacokinetics/Human plasma/Anticoagulant

Key words

Bivalirudin/LC-MS/MS/Pharmacokinetics/Human plasma/Anticoagulant

引用本文复制引用

Xiao-Jiao Li,Yan-Tong Sun,Lei Yin,Xue-Ju Zhang,Yan Yang,J.Paul Fawcett,Yi-Min Cui,Jing-Kai Gu..Quantitation of bivalirudin, a novel anticoagulant peptide,in human plasma by LC-MS/MS: Method development,validation and application to pharmacokinetics[J].药物分析学报(英文),2013,3(1):1-8,8.

基金项目

The authors are grateful to the National Natural Science Foundation (30973587),the China Postdoctoral Science Foundation (20110491328),and the National Natural Science Funds for Young Scholar (81102383) for financial support. (30973587)

药物分析学报(英文)

2095-1779

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