医药导报2012，Vol.31Issue(12)：1532-1535,4.DOI:10.3870/yydb.2012.12.002
左卡尼汀预处理对体外心脏保存效果的影响
Effect of L-carnitine Preconditioning of Rats on Storage of Their Hearts ex vivo
摘要
Abstract
Objective To observe the protective effects of L-carnitine ( LCN) preconditioning on rat hearts with cold preservation in St. Thomas No. 2 solution ex vivo. Methods Isolated rat heart Langendorff model was established. Twenty-four male Sprague-Dawley rats were randomly divided into three groups (8 rats in each group) : Sham group, the hearts were not arrested;I/R group and LCN preconditioning group,in which the rats were intraperitoneally injected with distilled water or LCN for 5 days respectively, and then the hearts were preserved in St. Thomas No. 2 solution ex vivo for 4 h. The recovery of myocardial function,heart resuscitation time,malonyldialdehyde (MDA) and wet weight in myocardium were analyzed. Results After the hearts were preserved for 4 h, there were no differences in the heart resuscitation time between I/R group and LCN preconditioning group[ (71. 24± 10. 48 ) s vs. (69. 42 ±9. 49) s ] , but LCN preconditioning group showed a better recovery of myocardial function,a lower release of MDA[ (2.71±0. 39) nmol·mg-1 vs. (3. 57±0.47) nmol·mg-1 ] ( P<0. 05) ,and the less wet weight in myocardium[ (69. 27±6. 52) % vs. (79. 42±5. 93 ) % ] ( P<0. 05 ) than that in I/R group. Conclusion LCN preconditioning exerts myocardial protective effects on the hypothermic preservative rat hearts ex vivo.关键词
左卡尼汀/预处理/心脏移植Key words
L-carnitine/Pharmacological preconditioning/Heart transplantation分类
医药卫生引用本文复制引用
周涛,秦国伟,向道康..左卡尼汀预处理对体外心脏保存效果的影响[J].医药导报,2012,31(12):1532-1535,4.基金项目
贵州省科技攻关项目(黔科合SY[2010]3119号) （黔科合SY[2010]3119号）
