医药导报2012，Vol.31Issue(12)：1550-1552,3.DOI:10.3870/yydb.2012.12.007
紫蓝素静脉注射的急性毒性实验
Acute Toxicity of Zilanine for Intravenous Injection in Rats
郏自明 1杨文祥 1谢运昌2
作者信息
- 1. 湖北省疾病预防控制中心,武汉430079
- 2. 广西壮族自治区植物研究所植物功能物质研究与利用重点实验室,桂林541006
- 折叠
摘要
Abstract
Objective To observe the acute toxicity of excessive zilanine for single intravenous injection in rats and evaluate their safety. Methods Sixty rats were randomly and evenly divided into three groups: zilanine group (700 mg·kg-1·d-1) ,3% NaHCOj group,and 0. 9% NaCl group. The toxicity symptoms and the starting and ending time of toxicity response of the rats were recorded. The rats were observed and recorded for 14 days. Results In zilanine group, the skin of the rats became purple,their dejecta was indigo,and the urine presented filemot two hours after the injection of zilanine, but they returned to normal on day 5. No rats died in zilanine group. The body weight and weight increment of zilanine group were significantly lower than those in 3% NaHC03 group and 0. 9% NaCl group. On day 1 , food intake in zilanine group was significantly lower than that in 3% NaHCO3 group and 0.9% NaCl group. The organ coefficient of kidney of zilanine group was significantly higher than that of 3% NaHC03 group and 0. 9% NaCl group. Zilanine caused pathological changes of the kidney in some rats. Conclusion The maximum tolerated dose of single intravenous injection was 700 mg·kg-1·d-1 for zilanine. The main toxicity is kidney toxicity in rats.关键词
紫蓝素/毒性/静脉注射/大鼠Key words
Zilanine/Toxicity/Intravenous injection/Rats分类
医药卫生引用本文复制引用
郏自明,杨文祥,谢运昌..紫蓝素静脉注射的急性毒性实验[J].医药导报,2012,31(12):1550-1552,3.
