医药导报2012，Vol.31Issue(12)：1573-1577,5.DOI:10.3870/yydb.2012.12.015
右美托咪定用于无创机械通气镇静30例
Efficacy and Safety of Dexmedetomidine in Patients with Noninvasive Ventilation
陆洋 1沈浩亮 1王林华 1崔晓莉 1张彬 1赵宏胜1
作者信息
- 1. 南通大学附属医院重症医学科,江苏226001
- 折叠
摘要
Abstract
Objective To investigate the efficacy and safety of continuous intravenous injection of dexmedetomidine in patients with noninvasive ventilation ( NIV). Methods Ninety patients with acute respiratory failure given NIV were randomly divided into three groups: dexmedetomidine group ( n=30 ) , midazolam group ( n = 30 ) , and non sedative group ( n=30 ). Dexmedetomidine was infused at a loading dose of 0. 5-1. 0 μg·kg-1·h-1 for 10 min followed by a maintenance dose of 0. 2-0.7 μg·kg-1·h-1 . Midazolam was infused at a loading dose of 0. 05 mg·kg-1 followed by a maintenance dose of 0. 03-0. 20 mg·kg-1·h-1. Vital signs, blood gas, bispectral index (BIS) and Riker Sedation-Agitation Scale (RSAS) were recorded before infusion (baseline) and at 1st ,4th,6th,8th, 12th and 24th h after dexmedetomidine administration. Intubation rate, NIV days, duration in intensive care unit ( ICU) and delirium were compared between the two groups. Results In sedative group, the clinical outcomes of vital signs,gas blood and reduced intubation rate,NIV days,duration in ICU were significantly improved ( P< 0.05 ) . In the dexmedetomidine group, there were no significant adverse effects on respiratory drive as compared with the midazolam group. The intubation rate was 10% ,NIV day (3. 7±1. 2) days,and the rate of delirium 12. 3% in the dexmedetomidine group, which were significantly lower than those in the midazolam group (P < 0. 05 ). While the duration in ICU had no significant difference between the two groups ( P>0. 05 ). Conclusion Proper sedation in patients with agitation may improve success rate of NIV. Dexmedetomidine has more advantages than midazolam in efficacy and safety of adaptation to NIV.关键词
右美托咪定/无创机械通气/镇静Key words
Dexmedetomidine/Noninvasive ventilation/Sedation分类
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陆洋,沈浩亮,王林华,崔晓莉,张彬,赵宏胜..右美托咪定用于无创机械通气镇静30例[J].医药导报,2012,31(12):1573-1577,5.
