应用化学2013，Vol.30Issue(1)：43-47,5.DOI:10.3724/SP.J.1095.2013.20021
3,5-二碘水杨醛缩邻苯二胺Ni(Ⅱ)配合物的合成及生物活性
Synthesis and Biological Activities of 3,5-Diiodo-salicylalidehyde and o-Diaminobenzene Schiff Base and Its Ni(Ⅱ) Complex
摘要
Abstract
The Schiff base consisted of 3 ,5-diiodo-salicyIalidehyde and o-diaminobenzene( L) and its Ni(Ⅱ) metal complex has been synthesized and characterized by 1H NMR,elemental analysis,UV spectra,IR spectra and molar conductance analysis.The main bond parameters of the complex were calculated by full-optimized molecular geometry using Gaussian03 program.The composition of the complex was determined to be Ni (Ⅱ) L.The binding mode between complex and DNA was investigated by UV spectra,viscosities,and DNA competitive binding with ethidium bromide ( EB).The results showed that the intensity of absorption peaks increased when the complex interacted with ct-DNA,and its constant was Kb = 1.129×105 L/mol.The complex will lead to dramatic decrease of fluorescent intensity of EB-DNA.The relative viscosity of cf-DNA increased with the concentration increase of the complex.All indicated that the complex was intercalated into ct-BNA.In addition,the complex is assayed against M.luteus by the punch method.关键词
含碘席夫碱/Ni(Ⅱ)配合物/光谱性质/DNA插入作用/抑菌活性Key words
iodine-containing Schiff base/Ni (Ⅱ) complex/spectrum property/DNA intercalative binding mode/antibacterial activity分类
化学化工引用本文复制引用
李晓红,杨天林,王敏,霍丽娜,李艳萍..3,5-二碘水杨醛缩邻苯二胺Ni(Ⅱ)配合物的合成及生物活性[J].应用化学,2013,30(1):43-47,5.基金项目
国家自然科学基金(20962016,21261018)、教育部科学技术研究重点基金(208159)资助项目 （20962016,21261018）
