湖北医药学院学报2012，Vol.31Issue(2)：130-132,136,4.
妊娠期高血压疾病患者血清MMP-9、TIMP-1表达水平与新生儿体质量的相关性研究
The Relationship of Expression of MMP-9 ,TIMP-1 in Serum of Pregnancy Induced Hypertension with Uygur Neonatal Body Mass
张玉毅 1李小英 2郭广林 1邓杰 1任红英 1王玉婷1
作者信息
- 1. 湖北医药学院附属襄阳医院,湖北襄阳441000
- 2. 新疆维吾尔自治区人民医院,新疆乌鲁木齐830001
- 折叠
摘要
Abstract
Objective To investigate the MMP-9, TIMP-1 expression levels of pregnancy-induced hypertension in serum in Xinjiang Uygur and provide the theoretical basis for clinical treatment of early intervention. Methods Matrix metalloproteinase-9, tissue inhibitors of metalloproteinase-1 levels were detected in 60 patients of Uygur women with pregnancy induced hypertension and 30 healthy Uygur women with pregnancy by ELISA assay. Results In severe hypertension group,newboms physical weight,head circumference,chest circumference,and length,were lower compared to slight and moderate hypertension group and healthy group; the levels of matrix metalloproteinase-9 of the severe pregnancy induced hypertension were lower than the healthy group and the mild PIH, there was a significant different (P < 0. 05);mild pregnancy-induced hypertension group and the normal group have no significant differences ( P > 0.05 ) ; there was not statistical significance in TIMP-1 (P>0.05) ,serum MMP-9 was positively correlated with neonatal weight (P <0.0001 ). Conclusion Pregnancy induced hypertension affect the newborn body mass,MMP-9 levels may be one of the factors affecting newborn body mass.关键词
妊娠期高血压疾病/基质金属蛋白酶-9/金属蛋白酶组织抑制因子1/维吾尔族/新生儿体质量Key words
Pregnancy induced hypertension/ Matrix metalloproteinase-9/ Tissue inhibitors of metalloproteinase-1/ Uygur/ Neonatal body mass分类
医药卫生引用本文复制引用
张玉毅,李小英,郭广林,邓杰,任红英,王玉婷..妊娠期高血压疾病患者血清MMP-9、TIMP-1表达水平与新生儿体质量的相关性研究[J].湖北医药学院学报,2012,31(2):130-132,136,4.
