湖北医药学院学报2012，Vol.31Issue(6)：458-463,6.
脱细胞真皮基质预防下颌阻生磨牙拔除术后并发症效果的Meta分析
Effectiveness of Acellular Dermal Matrix Prophylaxis in Mandibular Impacted Molars Extraction :A Meta-analysis
摘要
Abstract
Objective To evaluate the efficacy of acellular dermal matrix (ADM) prophylaxis in mandibular impacted molars (IM) extraction by performing a meta-analysis. Methods The PubMed, CENTRAL, SinoMed.CNKI, VIP, and Wanfang databases were searched from 1999 to July 2012,in order to retrieve relevant studies. Manual searching was also performed. After assessing the methodological quality and data extraction, a meta-analysis was conducted by using the Meta-Analyst 3. 13 software;and the levels of evidences were assessed according to GRADE system by using GRADEpro 3. 6 software. Results Twelve RCTs and CCTs involing 1 267 teeth(ADM group) were included. The meta-analysis showed that compared with blank control group,the ADM could obviously decrease the rate of dry socket(RR=0.14,95%CI =0.09 ~0.24,P< 0. 001) ,rebleeding(RR = 0. 34,95% CI =0. 20 ~ 0. 60,P < 0. 001) ,swelling( RR = 0. 58,95% CI =0. 35 ~ 0. 96,P = 0.04) ,and trismus( RR =0.72,95%CI =0.52~0.99,P =0.04) ;in sequence,the levels of evidences were high,morder-ate,very low,and low.Conclusions Based on current evidences,ADM can effectively reduce the complications after mandibular IM extraction.However,large sample,randomised,controlled,as an index of 'cost-benefit analysis' ,and according to CONSORT statement trails are suggested,before recommending ADM as a routine protocol.关键词
阻生磨牙/下颌/拔除/脱细胞真皮基质/Meta分析/GRADE系统Key words
Impacted molar/ Mandibular/ Tooth extraction/ Acellular dermal matrix/ Meta-analysis/ GRADE system分类
医药卫生引用本文复制引用
解龙川,徐晓明,曾宪涛..脱细胞真皮基质预防下颌阻生磨牙拔除术后并发症效果的Meta分析[J].湖北医药学院学报,2012,31(6):458-463,6.基金项目
湖北省教育科学"十二五"规划2012年度重点课题(2012A049),湖北医药学院2011年度优秀中青年科技创新团队项目(2011CZX01). （2012A049）
