湖北医药学院学报2012，Vol.31Issue(6)：464-467,4.
火棘多糖清除氧自由基及抗脂质过氧化作用
Effects of Pyracantha Fortuneana Polysaccharide on Scavenging Oxygen Free Radical and Anti-lipid Peroxidation
摘要
Abstract
Objective To investigate the effects of Pyracantha fortuneana polysaccharide on scavenging oxygen free radical and anti-lipid peroxidation. Methods Superoxide anion free radical (O2- · ) and hydroxyl free radical (OH · ) were induced with auto-oxidation of pyrogallol and Fenton system, then the effects of Pyracantha fortuneana polysaccharide on scavenging O2 - · and OH · were determined. The lipid peroxidation was induced with Fe2 + -H2O2 system in liver homogenate of healthy rats and CCL4-induced acute hepatic injury rats, then the effects of Pyracantha fortuneana polysaccharide on anti-lipid peroxidation were determined,moreover, the production of lipid peroxidation malondialdehyde( MDA) was measured by thiobarabituric acid(TBA) colorimetric method. Results Pyracantha fortuneana polysaccharide could significantly scavenge O2 - · and OH · and inhibit lipid peroxidation of healthy rat liver homogenate induced by Fe2+ -H2O2 system. The different dosage of Pyracantha fortuneana polysaccharide could significantly inhibit the lipid peroxidation of liver homogenate from a-cute hepatic injury rats induced with CCL4 in vitro( P < 0.01 and/or P < 0.05 ) , and decrease the contents of MDA in liver ( P <0.01 and/or P <0.05 ). Conclusion Pyracantha fortuneana polysaccharide possesses the effects of scavenging oxygen free radical and anti-lipid peroxidation.关键词
火棘多糖/氧自由基/脂质过氧化/抗氧化Key words
Pyracantha fortuneana polysaccharide/Oxygen free radical/Lipid peroxidation/Antioxidant分类
医药卫生引用本文复制引用
赵杰,孙设宗,官守涛,张红梅,丁爱玲..火棘多糖清除氧自由基及抗脂质过氧化作用[J].湖北医药学院学报,2012,31(6):464-467,4.基金项目
湖北省十堰市科学技术研究与开发计划项目(十科发[2009]30号045D) （十科发[2009]30号045D）
