中国病理生理杂志Issue(1)：174-178,5.DOI:10.3969/j.issn.1000-4718.2013.01.031
内源性一氧化氮在急性高原病中的研究进展
Roles of endogenous nitric oxide in acute mountain sickness
摘要
Abstract
Acute mountain sickness (AMS) is the greatest challenge of military medicine and wilderness medicine, as the increasing populations of entering Tibet and others who rapidly ascend to high altitude. AMS is considered as a kind of vascular dysfunction and disequilibrium of body fluid diseases induced by environmental stress. Studies reveal that endogenous nitric oxide (NO) , a predominant endogenous vessel dilator, plays a crucial role in the pathogenesis of AMS. The decreased production and blocked delivery of NO cause dysfunction of the vascular system in hypoxic situations. Subsequently , AMS develops under the facilitations of alterations in brain and pulmonary blood vessels. NO or L - arginine (the precursor of NO) can also be used to prevent and treat AMS. This review will summarize the progress on the roles of NO in the pathogenesis, pathophysiology, treatment and prophylaxis of AMS.关键词
一氧化氮/急性高原病Key words
Nitric oxide/ Acute mountain sickness分类
医药卫生引用本文复制引用
卞士柱,黄岚..内源性一氧化氮在急性高原病中的研究进展[J].中国病理生理杂志,2013,(1):174-178,5.基金项目
国家卫生部卫生行业专项基金资助项目(No.201002012) （No.201002012）
