中国病理生理杂志2013，Vol.29Issue(2)：214-218,5.DOI:10.3969/j.issn.1000-4718.2013.02.005
L-4F改善狼疮样小鼠肾脏病变
L-4F attenuates the injury of lupus nephritis in a lupus mouse model
摘要
Abstract
AIM: To investigate the effects of apolipoprotein A-I mimetic peptide L-4F on the process of ne-phropathia in apoE-/-Fas-/- C57BL/6 lupus mice. METHODS: The apoE-/-Fas-/-C57BL/6 lupus mice (8 ～ 9 weeks old, female) were treated with L-4F by peritoneal injection for 25 weeks. RESULTS; Compared with the vehicle controls, the mice treated with L-4F presented smaller lymph nodes and glomerular tufts (P <0. 05) , lower serum levels of IgG antibodies to double-stranded DNA (P <0. 05) and oxidized phospholipids, as well as lower levels of inflammatory factors including IL-6 and TNF-a (P <0. 05) . Furthermore, serum adiponectin level in apoE-/- Fas/- C57BL/6 mice was significantly increased after L-4F treatment for 25 weeks. CONCLUSION: L-4F treatment significantly attenuates the development of lupus nephritis in apoE -/- Fas-/- C57BL/6 lupus mice, indicating a potential clinical value of L-4F in the treatment of lupus nephritis.关键词
载脂蛋白A-I模拟肽/狼疮肾炎/模型,小鼠Key words
Apolipoprotein A1 mimetic peptide/ Lupus nephritis/ Models,mice分类
医药卫生引用本文复制引用
吴帆,张普,俞佳文,卢婷婷,李校堃,林灼锋..L-4F改善狼疮样小鼠肾脏病变[J].中国病理生理杂志,2013,29(2):214-218,5.基金项目
温州市科技计划项目(No.H20100026) （No.H20100026）
