中国病理生理杂志2013，Vol.29Issue(2)：248-254,7.DOI:10.3969/j.issn.1000-4718.2013.02.011
高频起搏犬房颤模型心房重塑及窦房结和房室结功能的变化
Effect of high-rate left atrial pacing on atrial remodeling and functions of sinoatrial node and atrioventricular node in dogs
摘要
Abstract
AIM: To determine whether sinoatrial node (SAN) and atrioventricular node (AVN) undergo functional remodeling during atrial fibrillation (AF). METHODS; The Beagle dogs were randomized into pacing group (n =9)and control group (n = 6) . In open-chest dogs, the electrode catheters were sutured at left atria for pacing and data recording. SAN and AVN conductive properties were studied. The dogs in pacing group underwent 4 weeks of high-rate left atrial pacing (400 min-1 ) . The dogs in control group were not subject to pacing. RESULTS; The animal model of chronic AF was successfully established by pacing the left atrium at 400 min-1 in the dogs. Two of those animals were recorded with spontaneous AF at the end of 2 weeks, and the induction rate of AF reached 100% following 4 weeks of pacing. The incidences of paroxysmal AF and permanent AF were significantly increased by pacing compared to control group. After 4 weeks of pacing, atrial effective refractory periods ( AERP) at various at pacing cycle lengths (PCL; 250 ms, 300 ms and 350 ms) were all statistically shorter than those in control group. Compared with control group, a longer AVN Wenckebach point [ (294. 44 ±26. 06) min-1 vs (328. 33 ±24. 01) min-1 ,P<0.05] and longer atrioventricular node effective refractory period ( AVERP) (P <0. 01) in pacing group were observed. The sinus node recovery time (SNRT) and corrected SNRT both showed significant increases. No significant change of P-wave and PA interval between the two groups was found. The left atrial dimensions (anteroposterior, superoinferior and left-right diameters) and the right atrial superoinferior diameter were measured to be significantly increased after 2 weeks of pacing. CONCLUSION: The animal model of left atrium pacing can induce AF occurrence with a higher incidence. The characteristic electrophysiological indexes about atria, AVN and SAN were observed during AF in the canine model, indicating that electrical and structural remodeling accompanies with AVN and SAN remodeling during AF.关键词
心房纤颤/窦房结/房室结/重塑Key words
Atrial fibrillation/ Sinoatrial node/ Atrioventricular node/ Remodeling分类
医药卫生引用本文复制引用
刘丽娟,姚凤娟,彭龙云,李嘉翔,卢贵华,劳妙婵,陈宣兰,吴素华,高修仁..高频起搏犬房颤模型心房重塑及窦房结和房室结功能的变化[J].中国病理生理杂志,2013,29(2):248-254,7.基金项目
广东省社会发展计划重点项目(No.2010B031500027) （No.2010B031500027）
