中国病理生理杂志2013，Vol.29Issue(2)：255-260,6.DOI:10.3969/j.issn.1000-4718.2013.02.012
应用CT评价急性肺栓塞对家兔心功能的影响
Application of CT to investigate cardiac function in rabbits with acute pulmonary embolism
摘要
Abstract
AIM: To study the mechanisms of acute pulmonary embolism (APE) in rabbits by investigating the cardiac structures and functions through electrocardiography ( ECG) -gated 64 slice computed tomography ( CT). METHODS; The rabbit model of APE was established by injecting autologous blood clots. ECG-gated 64 slice CT detection was applied before and 2 h, 4 h and 8 h after APE. The left ventricular end-diastolic volume (LVEDV) , left ventricular end-systolic volume (LVESV) , right ventricular end-diastolic volume (RVEDV) , right ventricular end-systolic volume (RVESV) , left ventricular end-diastolic diameter (LVEDD) , left ventricular end-systolic diameter (LVESD) , right ventricular end-diastolic diameter (RVEDD) and right ventricular end-systolic diameter (RVESD) were determined by Volume and View softwares through CT reconstruction. RESULTS: No significant change of LVESV and LVESD after APE was observed. The RVEDV, RVESV, RVEDD and RVESD significantly increased 2 h, 4 h and 8 h after APE. The LVEDV, LVEDD, the left ventricular stroke volume (LVSV) and right ventricular stroke volume (RVSV) decreased 2 h, 4 h and 8 h after APE. The thrombosis in large pulmonary arteries displayed eccentric filling defect, and branch defect was showed in small pulmonary arteries. Compared with the anatomic examination, the accuracy of detecting large artery thrombosis by ECG-gated 64 slice CT was up to 100%. CONCLUSION: Enlarged right ventricle and decreased LVSV and RVSV are the characteristics of APE. ECG-gated 64 slice CT displays the important value in the judgment of the cardiac dysfunction after APE.关键词
肺栓塞/计算机断层成像/心功能Key words
Pulmonary embolism/ Computed tomography/ Cardiac function分类
医药卫生引用本文复制引用
阮丽波,李树清,金会艳..应用CT评价急性肺栓塞对家兔心功能的影响[J].中国病理生理杂志,2013,29(2):255-260,6.基金项目
国家自然科学基金资助项目(No.30971171) （No.30971171）
