中国当代儿科杂志2013，Vol.15Issue(2)：102-104,3.DOI:10.7499/j.issn.1008-8830.2013.02.007
γ-氨基丁酸治疗对哮喘患儿血浆P物质和降钙素基因相关肽含量的影响
Effect of gamma-aminobutyric acid treatment on plasma substance P and calcitonin gene-related peptide levels in children with asthma
摘要
Abstract
Objective To study the changes in plasma substance P (SP) and calcitonin gene-related peptide (CGRP) levels in children with acute asthma before and after gamma-aminobutyricacid (GABA) treatment. Methods Seventy-five children with asthma were randomly assigned to GABA treatment ( n = 36 ) and control groups ( n = 39 ) . Both groups were given conventional treatment for asthma. Besides the conventional treatment, the treatment group was administered with oral GABA (25 - 30 mg/kg·d). Plasma content of SP and CGRP was measured using ELISA before treatment and after remission. Results There were no significant differences in plasma content of SP and CGRP between the GABA treatment and control groups (P > 0.05) before treatment. Plasma content of SP and CGRP in the GABA treatment group was significantly lower than the control group (SP: 57 ± 15 pg/mL vs 127 ± 12 pg/mL; CGRP: 23 ± 10 pg/mL vs 42 ± 8 pg/mL) after remission (P<0. 01). Plasma content of SP and CGRP after remission was significantly lower than before treatment (P <0.01) in both groups. There was a significantly positive correlation between plasma SP and CGRP content in asthmatic children (r = 0. 792, P < 0.01). Conclusions GABA can significantly decrease plasma levels of SP and CGRP in children suffering from acute asthma.关键词
γ-氨基丁酸/P物质/降钙素基因相关肽/哮喘/儿童Key words
Gamma-aminobutyricacid/ Substance P/ Calcitonin gene-related peptide/ Asthma/ Child引用本文复制引用
徐传伟,郭山春,郑振文,王庆元..γ-氨基丁酸治疗对哮喘患儿血浆P物质和降钙素基因相关肽含量的影响[J].中国当代儿科杂志,2013,15(2):102-104,3.基金项目
滨州市科技发展计划(政策引导类)项目(编号:2011ZC0930). （政策引导类）
