中国当代儿科杂志2013，Vol.15Issue(2)：112-116,5.DOI:10.7499/j.issn.1008-8830.2013.02.010
新生儿重症监护室患儿院内感染病原菌分布及院内感染的危险因素分析
Pathogen distribution and risk factors of nosocomial infections in neonates in the neonatal intensive care unit
杨玲蓉 1彭珉娟 1李桦 1庞毅1
作者信息
- 1. 重庆医科大学附属成都第二临床学院/成都市第三人民医院儿科,四川成都610031
- 折叠
摘要
Abstract
Objective To study the pathogen distribution and risk factors of nosocomial infections in neonates in the neonatal intensive care units (NICU). Methods The clinical data of 145 neonates with nosocomial infection in the NICU were retrospectively reviewed. Results Of the 145 neonates, 41 (28. 3% ) were infected with Klebsiella pneumoniae, 39 (26. 9% ) with Escherichia coli, 10 (6.9%) with Staphylococcus epidermidis, and 55 (37.9%) with other pathogens. Logistic regression analysis showed that a gestational age of ≤32 weeks (OR = 5.57), birth weigh of < 1500 g (OR = 6.95), hospitalization time ( OR = 1.23 ) , mechanical ventilation (OR = 14.12) and parenteral nutrition ( OR = 3.01) were major risk factors for nosocomial infections caused by Klebsiella pneumoniae. The five factors were also main risk factors for nosocomial infection caused by Escherichia coli, with the OR of 3.42, 6.73, 9.96, 0.55 and 2.13 respectively. Klebsiella pneumoniae and Escherichia coli were highly resistant to p-lactam antibiotics but were relatively sensitive to levofloxacin and meropenem. Conclusions Klebsiella pneumoniae, Escherichia coli and Staphylococcus epidermidis are major pathogens of nosocomial infections in neonates in the NICU and they are resistant to p-lactam antibiotics. Mechanical ventilation and hospitalization time are the most important risk factors for nosocomial infections caused by Klebsiella pneumoniae and Escherichia coli respectively.关键词
重症监护室/肺炎克雷伯杆菌/大肠埃希菌/院内感染/新生儿Key words
Intensive care unit/ Klebsiella pneumonia/ Escherichia coli/ Nosocomial infection/ Neonate引用本文复制引用
杨玲蓉,彭珉娟,李桦,庞毅..新生儿重症监护室患儿院内感染病原菌分布及院内感染的危险因素分析[J].中国当代儿科杂志,2013,15(2):112-116,5.
