中国动脉硬化杂志2013，Vol.21Issue(1)：52-56,5.
瑞舒伐他汀与阿托伐他汀对冠心病患者Rho激酶活性和内皮功能影响的比较
Effect of Rosuvastatin Versus Atorvastatin on ROCK Activity and Endothelial Function in Patients with Atherosclerosis
吴丁烨 1冯健 1尤华彦 1王强 1曹华明 1钟艳芳2
作者信息
- 1. 南京医科大学附属无锡人民医院心血管内科,江苏省无锡市214023
- 2. 南京医科大学附属无锡人民医院神经内科,江苏省无锡市214023
- 折叠
摘要
Abstract
Aim To compare the short-term effects of rosuvastatin and atorvastatin on serum lipids and markers of inflammation and endothelial function in patients with stable atherosclerosis. Methods Thirty-six patients with stable atherosclerosis were randomly assigned to receive 10 mg/day of rosuvastatin or 20 mg/day atorvastatin for 4 weeks. The change in the levels and patterns of lipoproteins, high-sensitivity C-reactive protein (hs-CRP) , Rho-associated coiled-coil-containing protein kinase activity( ROCK) , and brachial artery flow-mediated dilation (FMD) of the brachial artery were assessed before and after statin therapy. Results Rosuvastatin and atorvastatin both significantly lowered levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, and hs-CRP from baseline values, and increased levels of hs-CRP and FMD. Both statins inhibited R0CK( P ＜0. 05 ) , the extent of inhibition was greater with rosuvastatin ( P ＜ 0. 05). ROCK and FMD was correlated to each other(P ＜0. 05). But ROCK was not correlated with the levels of low density lipoprotein cholesterol (LDLC). FMD was not correlated with the levels of LDLC adn hs-CRP. Conclusions Short-term treatment with either rosuvastatin or atorvastatin inhibits ROCK and improves endothelium dysfunction in patients with atherosclerosis. But rosuvastatin inhibits ROCK even more than atorvastatin.关键词
瑞舒伐他汀/阿托伐他汀/内皮功能/Rho激酶活性/动脉粥样硬化Key words
Atorvastatin/ Rosuvastatin/ Endothelial Function/ ROCK Activity/ Atherosclerosis分类
医药卫生引用本文复制引用
吴丁烨,冯健,尤华彦,王强,曹华明,钟艳芳..瑞舒伐他汀与阿托伐他汀对冠心病患者Rho激酶活性和内皮功能影响的比较[J].中国动脉硬化杂志,2013,21(1):52-56,5.
