中国动脉硬化杂志2013，Vol.21Issue(1)：84-88,5.
Rho激酶:他汀类药物抗动脉粥样硬化的重要靶点
Rho Kinase: Important Targets for the Treatment of Atherosclerosis by Statins
孙由静 1张闻多 1汪芳1
作者信息
- 1. 卫生部北京医院心内科,北京市100730
- 折叠
摘要
Abstract
As the classic drugs for treatment of atherosclerosis, statins' cholesterol-independent or pleiotropic effects are attracting more and more attention. Recent experimental and clinical studies have indicated the close relationship between Rho kinase and the pleiotropic effects of statins. Moreover, many studies abroad have suggested that the inhibition of Rho kinase could be a promising target for the treatment of cardiovascular disease. In this review, we will summarize the structure and activation of the Rho kinase, discuss the relationship between Rho kinase and atherosclerosis, and illustrate the Evidence-Based evidences and mechanisms of statins' inhibition of Rho kinase, meanwhile, this article will also prospect the therapeutic potential of Rho kinase in the treatment of atherosclerosis and vascular disease in future.
关键词
Rho激酶/他汀类药物/动脉粥样硬化/多效性Key words
Rho Kinase/ Statins/ Atherosclerosis/ Pleiotropic分类
医药卫生引用本文复制引用
孙由静,张闻多,汪芳..Rho激酶:他汀类药物抗动脉粥样硬化的重要靶点[J].中国动脉硬化杂志,2013,21(1):84-88,5.
