中国动脉硬化杂志2013，Vol.21Issue(2)：149-153,5.
烟酸对实验性动脉粥样硬化兔主动脉骨桥蛋白表达的影响
Effect of Nicotinic Acid on Plaques Formation and Expression of Osteopontin mRNA in Aorta of Experimental Atherosclerosis Rabbit
摘要
Abstract
Aim To investigate the effects of nicotinic acid on the atherosclerotic plaques formation and osteopontin ( OPN) mRNA expression of aorta. Methods 16 New Zealand white rabbits were fed with high-fat diet for 8 weeks, and then were randomly divided into two groups: (1) hyperlipidemia group ( n = 8) ; maintained high-fat diet for 6 weeks; (2)niacin treatment group (n=8) : the same fat diet supplemented with niacin [200 mg/(kg·d) ] for 6 weeks. Control group ( n - 8 ) was fed with normal diet for 14 weeks. At the end of the study, all rabbits were sacrificed to detect the histopathological changes and OPN mRNA expression of the aortas. Results Rabbits fed with high-fat diet showed more aorta endometrial thickness, plaque area and OPN mRNA expression (all P ＜ 0. 01 ). Compared with hyperlipidemia group, rabbits treated with niacin showed less aorta endometrial thickness, plaque area and OPN expression (all P ＜ 0. 01) . Correlation analysis suggested that expressions of OPN mRNA ( r = 0. 888, P ＜ 0. 01 ) and OPN protein ( r = 0. 821 , P ＜ 0. 01) were positively correlated with area of atherosclerotic plaque, expressions of OPN mRNA (r = 0. 874, P ＜ 0. 01) and OPN protein (r = 0. 818, P ＜ 0. 01) were also positively correlated with intimal thickness of aorta. Conclusion Niacin' s role of anti-atherosclerosis not only is due to its lipid-lowering effect, but also may be related to its OPN expression-lowering effect.关键词
烟酸/动脉粥样硬化/骨桥蛋白Key words
Nicotinic Acid/ Artery Atherosclerosis/ Osteopontin分类
医药卫生引用本文复制引用
文伟明,雷敏,徐戈,李志乐..烟酸对实验性动脉粥样硬化兔主动脉骨桥蛋白表达的影响[J].中国动脉硬化杂志,2013,21(2):149-153,5.基金项目
广西青年科学基金资助(桂科青0832049) （桂科青0832049）
