中国动脉硬化杂志2013，Vol.21Issue(2)：169-172,181,5.
阻塞性睡眠呼吸暂停综合征患者血清25-羟维生素D浓度与左心室肥厚的关系
Serum 25-Hydroxy Vitamin D Concentration is Positively Related to Left Ventricular Hypertrophy in Obstructive Sleep Apnea-hypopnea Syndrome Patients
李帅兵 1杨帆 1荆莉 1马娟 1贾亚丹 1董少英 1郑卫峰 1赵洛沙1
作者信息
- 1. 郑州大学第一附属医院心内科,河南省郑州市450052
- 折叠
摘要
Abstract
Aim To investigate whether increased plasma levels of serum 25 -hydroxy vitamin D [25 (OH) VD] are associated with cardiac structural and functional abnormalities in obstructive sleep apnea-hypopnea syndrome ( OSAHS) patients. Methods We documented 337 consecutive patients with OSAHS. Left ventricular hypertrophy ( LVH) [ left ventricular mass index (LVMI) ≥125 g/m2 in male, and LVMIS=120 g/m2 in female] was determined by echocardiography. The serum 25-hydroxy vitamin D concentration was measured by using enzyme-linked immunosorbent assay (ELJSA) method. Results The LVMI, prevalence rate of LVH and body mass index (BMI) were higher in the subjects with severe OSAHS (apnoea-hypopnoea index ≥30/h, LVH 75% , n = 226) than in those with mild to moderate OSAHS (LVH 40% , n = 111) (P ＜ 0. 01) , and serum 25 (OH) VD levels were lower in the severe OSAHS groups. Although the serum 25 ( OH) VD level showed a negative correlation with BMI, the results of binary logistic regression analysis demonstrated that the quar-tile value of 25 ( OH) VD was an independent significant variable for the identification of LVH ( adjusted OR in quartile = 4. 11, 95% CI: 1. 15-12. 70, P＜0.01), even after adjusting for obesity and other risk factors. Conclusion Decreased serum levels of 25(OH) VD do seem to reflect an increased likelihood of LVH in patients with severe OSAHS.关键词
阻塞性睡眠呼吸暂停综合征/25-羟维生素D/左心室肥厚Key words
Obstructive Sleep Apnea-hypopnea Syndromes/ 25-Hydroxy Vitamin D/ Left Ventricular Hypertrophy分类
医药卫生引用本文复制引用
李帅兵,杨帆,荆莉,马娟,贾亚丹,董少英,郑卫峰,赵洛沙..阻塞性睡眠呼吸暂停综合征患者血清25-羟维生素D浓度与左心室肥厚的关系[J].中国动脉硬化杂志,2013,21(2):169-172,181,5.
