摘要
Abstract
Objective To investigate the distribution and change in antimicrobial resistance of Acinetobacter bau-mannii (AB) in healthcare-associated infection(HAI) in a hospital,so as to provide reference for rational use of antimicrobial agents. Methods AB isolated from clinical specimens between January 2008 and December 2011 were identified with Vitek 2-compact microbiology analyzer, antimicrobial susceptibility testing was performed by Kirby-Bauer disk diffusion method. Results A total of 597 AB isolates were isolated. The percentage of AB in gram-negative bacilli from 2008 to 2011 was 7. 00% ,8. 35% ,9. 75% , and 12. 66% respectively, percentage in 2011 rose obviously compared with 2008 (χ2 = 32. 77,P<0. 05). The major specimen was sputum (70. 86%), AB distributed mainly in elderly ward(177 isolates,29. 65%) , oncology department(115 isolates, 19. 26%) , and neurology depart-ment(93 isolates,15. 58%). Antimicrobial resistant rate of AB increased yearly during four years (P<0. 05),and resistant rate in 2011 to meropenem,cefoperazone/sulbactam and minocycline was low (8. 56%,6. 95%,5. 35%,respectively). Conclusion Infection and antimicrobial resistant rate of AB rise constantly, strengthening the monitoring on AB is beneficial to guide rational use of antimicrobial agents in clinical practice and reduce the emergence and spread of drug-resistant strains.关键词
鲍曼不动杆菌/医院感染/抗药性,微生物/多重耐药/抗菌药物Key words
Acinetobacter baumannii/ healthcare-associated infection/ drug resistance, microbial/ multidrug resistance/ antimicrobial agent分类
医药卫生
