中国骨伤2013，Vol.26Issue(2)：175-178,4.DOI:10.3969/j.issn.1003-0034.2013.02.024
关节软骨损伤和缺损修复策略
Research on repair strategies for articular cartilage defects
摘要
Abstract
Articular cartilage damage is very common in clinical practices. Due to the low self-healing abilities of articular cartilage,the repair strategies for articular cartilage such as arthroscopic lavage and debridement,osteochondral or chondro-cytes transplantation, tissue engineering and hydrogel based artificial cartilage materials are the primary technologies of repairing articular cartilage defect. In this paper,the main repair strategies for the articular cartilage damage and the advantages or disadvantages of each repair technology are summarized. The arthroscopic lavage and debridement is successful in treating the early stage of osteoarthritis. Osteochondral and chondrocytes transplantation are beneficial to treat small full thickness defects. The technology of tissue engineering becomes a new method to heal articular cartilage damage,but the major problem is the absence of bonding strength between the implants and natural defect surfaces. Hydrogel based artificial cartilage possesses similar bio-mechanical and bio-tribological performances to that of natural articular cartilage. However,both bioactivity and in-terfacial bonding strength between the implant and natural cartilage could be further improved. How to simultaneously optimize the mechanical and bioactive as well as biotribological properties of hydrogel based materials is a focus problem concerned.关键词
软骨,关节/创伤和损伤/综述文献Key words
Cartilage, articular/Wounds and injuries/Review literature引用本文复制引用
潘育松,丁国新,王静..关节软骨损伤和缺损修复策略[J].中国骨伤,2013,26(2):175-178,4.基金项目
国家自然科学基金资助项目(编号:51175004) （编号:51175004）
安徽高校省级自然科学基金重点资助项目(编号:KJ2010A099) （编号:KJ2010A099）
