中国临床心理学杂志2012，Vol.20Issue(6)：769-772,4.
慢性束缚应激对小鼠毛囊细胞生长周期的影响
Influence of Chronic Restraint Stress on Anagen Stage in Skin of Mouse
刘楠 1马占波 2傅文青 1张国兴 1王琳辉 1王晓娟1
作者信息
- 1. 苏州大学基础医学与生物科学学院,江苏苏州215123
- 2. 河北省衡水市东亚百殿风医院,河北衡水053000
- 折叠
摘要
Abstract
Objective: To investigate the effects of oxidative stress induced by chronic restraint stress on hair cycle of mouse. Methods: Chronic restraint stress was used to establish a psychological stress model in mouse, to observe the change of behavior and skin tissue morphology, and detect the cortisol levels in plasma, thiobarbituric acid reactive sub-stances (TBARS) levels, superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) activity in skin. Results: Com-pared with the control group, mouse movement distance of restraint group decreased significantly (P<0.05), plasma cortisol and skin TBARS levels increased significantly (P<0.05, P<0.001), SOD and GSH-Px activity decreased significantly (P< 0.05, P<0.001), anagen stage was significantly delayed; Compared with the control group, TBARS levels and GSH-Px ac-tivity had no significant difference in mouse of restraint added anti-oxidants group, delay of anagen was partly reversed. Conclusion: The oxidative stress induced by chronic restraint stress of skin tissue delayed anagen in hair cycle of mouse.关键词
慢性束缚应激/氧化应激/毛囊周期Key words
Chronic restraint stress/Oxidative stress/Hair cycle分类
医药卫生引用本文复制引用
刘楠,马占波,傅文青,张国兴,王琳辉,王晓娟..慢性束缚应激对小鼠毛囊细胞生长周期的影响[J].中国临床心理学杂志,2012,20(6):769-772,4.
