中国临床药理学杂志2013，Vol.29Issue(1)：3-5,41,4.
CYP2C9基因多态性对中国心脏机械瓣置换患者华法林初始抗凝效果的影响
Effects of CYP2C9 genetic polymorphisms on response to warfarin during initial anticoagulation in Chinese patients with mechanical heart valve replacement
摘要
Abstract
Objective To evaluate the effects of CYP2C9 genetic polymorphisms on response to warfarin during initial anticoagulation in Chinese patients with mechanical heart valve replacement. Methods In 254 Chinese valve replacement patients starting warfarin therapy, the CYP2C9 genotypes ( CYP2C9 * 1, * 2, and * 3 ) were assessed. The study outcomes included the time to the first International Normalized Ratio (INR) reach the therapeutic range, the total warfarin doses in initial 5 days, and whether INR within the therapeutic range in the day 6. Results Compared with patients with the * 1/ * 1 genotype, patients with the * 2 or * 3 genotype of CYP2C9 had the same time to the first INR reach the therapeutic range (P =0. 933) and no difference in total warfarin doses in initial 5 days (P =0.669). However, the CYP2C9 genotype was a significant predictor of INR within the therapeutic range in the day 6. Conclusion CYP2C9 genetic polymorphisms only affected INR within the therapeutic range in the day 6 in Chinese patients with mechanical heart valve replacement.关键词
华法林/CYP2C9基因多态性/初始抗凝Key words
warfarin/CYP2C9 genetic polymorphism/ initial anticoagulation分类
医药卫生引用本文复制引用
娄莹,谢爽,刘红,韩璐璐,许莉,李一石..CYP2C9基因多态性对中国心脏机械瓣置换患者华法林初始抗凝效果的影响[J].中国临床药理学杂志,2013,29(1):3-5,41,4.基金项目
国家科技重大专项基金资助项目(2011ZX09304) （2011ZX09304）
心血管创新药物临床研究技术平台建设基金资助项目(2012ZX09303008-001) （2012ZX09303008-001）
