中国临床药理学杂志2013，Vol.29Issue(1)：38-41,4.
α-细辛醚抗癫痫作用的实验研究
Experimental tudy on the antiepileptic properities of alpha-asarone in the Lithium -pilocarpine model of temporal lobe epilepsy
摘要
Abstract
Objective To investigate the antiepileptic properties and effects on learning and memory performances of alpha - asarone in Lithium -pilocarpine model of temporal lobe epilepsy. Methods Graded doses of α - asarone (50, 100 and 200 mg · kg-1 ) were administered orally to the rats, the effect of alpha - asarone on electroencephalogram alterations , spontaneous seizures as well as learning and memory performances in Lithium - Pilocarpine rats were investigated. Results α - asarone prolonged the Spontaneous recurrent seizure latency and reduced the seizure frequency as well as the seizure severity in Lithium - pilocarpine chronic models. It significantly prolonged the latency of abnormal discharge and reduced the discharge frequency induced by Lithium - pilocarpine. It significantly decreased the escape latency in Morris water maze test and prolonged the percentage in average for staying time of rats at A quandrant in spatial bias test. The higher dose (200 mg · kg -1 , po) was found to be effective when compared with the lower dose (50 and 100 mg · kg-1 ). Conclusion α - asarone improved the learning and memory ability in Lithium - pilocarpine rats. The mechanism seems to be related to its role in controlling seizure and depressing epileptic discharge.关键词
α-细辛醚/癫痫/认知功能Key words
alpha - asarone/ epilepsy/ cognitive function分类
医药卫生引用本文复制引用
苗静琨,陈启雄,李春,李晓文,刘振球,吴小玫,张晓萍..α-细辛醚抗癫痫作用的实验研究[J].中国临床药理学杂志,2013,29(1):38-41,4.基金项目
重庆医科大学博士启动基金资助项目(0200101060) （0200101060）
